The “Smoker’s Paradox”
نویسندگان
چکیده
منابع مشابه
Enhanced clopidogrel responsiveness in smokers: smokers' paradox is dependent on cytochrome P450 CYP1A2 status.
OBJECTIVE Observational studies have reported enhanced response to clopidogrel in smokers (the smokers' paradox). We examined whether genetic variations in the cytochrome and drug transporter system are associated with the effect of smoking on clopidogrel response. METHODS AND RESULTS Clopidogrel on-treatment platelet reactivity (OPR) was measured in 1431 consecutive patients who underwent co...
متن کاملClinical and Population Studies Enhanced Clopidogrel Responsiveness in Smokers Smokers’ Paradox Is Dependent on Cytochrome P450 CYP1A2 Status
Objective—Observational studies have reported enhanced response to clopidogrel in smokers (the smokers’ paradox). We examined whether genetic variations in the cytochrome and drug transporter system are associated with the effect of smoking on clopidogrel response. Methods and Results—Clopidogrel on-treatment platelet reactivity (OPR) was measured in 1431 consecutive patients who underwent coro...
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ژورنال
عنوان ژورنال: JACC: Cardiovascular Interventions
سال: 2019
ISSN: 1936-8798
DOI: 10.1016/j.jcin.2019.07.028